DNA Synthesis Reagents and Columns
AdipoGen CA771
Chemical. CAS 2412270-22-3. Formula C16H12ClN3O. MW 297.7. CA77.1 is a novel selective chaperone-mediated autophagy CMA activator by increasing the expression of the lysosomal receptor for this pathway, LAMP2A, in lysosomes. Chaperone-mediated autophagy CMA, is a selective autophagy shown to degrade neurodegeneration-related proteins such as alpha-synuclein alpha-syn or tau. Loss of neuronal CMA leads to altered neuronal function, selective changes in the neuronal metastable proteome and proteotoxicity. Chemical upregulation of CMA has been shown to ameliorate pathology in AD experimental mouse models, reduce brain pathology and improve disease phenotype. CA77.1 is able to activate CMA in vitro and in vivo in contrary to its derivative AR7 which was not suitable for in vivo application. CA77.1 is able to activate CMA in vivo, and demonstrates brain penetrance and favorable pharmacokinetics.
Clontech Labs 3P 1ST STRAND CDNA SYNTHESIS KIT
6110A PrimeScript(TM) 1st strand cDNA Synthesis Kit 50 Rxns
Advanced Chemblocks Inc CIS 4 AMINOMETHYL TETRAHYD 1G
cis-4-(Aminomethyl)tetrahydro-3-furanol, 1g, 1630906-62-5
New England Biolabs, Inc. ProtoScript First Strand cDNA Synthesis Kit – 150 reactions
ProtoScript First Strand cDNA Synthesis Kit features two optimized mixes, M-MuLV Enzyme Mix and M-MuLV Reaction Mix. M-MuLV Enzyme Mix combines M-MuLV Reverse Transcriptase and Murine RNase Inhibitor, while M-MuLV Reaction Mix contains dNTPs and an optimized buffer. The kit also contains two optimized primers for reverse transcription and nuclease-free water. An anchored oligo-dT primer [d(T)23VN] forces the primer to anneal to the beginning of the polyA tail. The optimized Random Primer Mix provides random and consistent priming sites covering the entire RNA template including both mRNAs and non-polyadenylated RNAs. The first strand cDNA product generated is more than 10 kb.
BIOSEARCH TECHNOLOGIES INC INVERSE ABASIC CNA CPG LOW BUL
Inverse Abasic CNA CPG Low Bulk Density, 600 A, 80-90 µmol/g, BULK (g)